Back In 1895 Hericourt and Richet described the first trials in which cancer cells were injected into animals to raise an antiserum for treating the
patient. None of them were cured, but they showed significant improvements in their symptoms. During the early 1900's many workers repeated these trials, but found nothing, leading to the conclusion in 1929 that nothing will work. It was discovered that an antiserum contains a mixture of many different antibodies, each one directed against a different antigen on the cancer cells. Many of these antigens are also present on normal tissue cells and so the antibodies against them could be harmful. In 1975 Kohler and Milstein found what first envisaged 80 years earlier. Since then a prodigious number of different monoclonal
antibodies have been made and they have been exploited in almost every
branch of biomedical research. Several have been found which recognise human
cancers and some of these have been tested in clinical trials.......
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