Clinical trials have demonstrated the efficacy of cognitive-behavioral treatment (CBT) for panic disorder but the mechanism responsible for the improvement are lacking. The reduction of fear of fear (FOF), or the tendency to respond fearfully to benign bodily sensations, is believed to underlie the improvement resulting from CBT. Research has provided evidence consistent with the FOF hypothesis. Descriptive studies consistently show that panic disorder patients score significantly higher on self-report measures tapping fear of bodily sensations. Those who score high on measures tapping FOF display heightened emotional responding to challenge compared with those who score low on these same FOF measures (M. Brown, Smits, Powers, & Telch, 2003; Eke & McNally, 1996; Holloway & McNally, 1987; McNally & Eke, 1996; Rapee & Medoro, 1994; Telch et al., 2003). Findings from several prospective studies suggest that people score big on the Anxiety Sensititivity Index (ASI) are at greater......
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