I. What is Tay-Sachs..?
A. Simple Facts
1. Named after Warren Tay and Bernard Sachs
2. Involves protein ganglioside GM2 and enzyme Hex-A
3. Gene mutation located in Chromosome 15
B. Cause
1. Cause by lack of protein enzyme Hex-A
2. Inherited from both parents
3. Ganglioside GM2 accumulates abnormally in the brain
C. Victims
1.Found in the Ashkenazi Jews
a. 1 out of 27 Jews is affected
2. Found in French-Canadians
a. 1 out of 250 people affected
3. Found in Louisiana Cajuns
a. 1 out of 27 people affected
D. How to diagnose it
1. Diagnosis in adults results in blood testing
a. If the Hex-A measurements are high, the test results positive
2. Diagnosis in stages of infancy
a. After 6 or 7 months, the child will have stopped moving or
showing healthy signs in the womb.
II. Tay-Sachs and its outcomes
A. Effects of Tay-Sachs......
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